By Lazaros C. Triarhou
This ebook is the fruits of fifteen years of study at the transplantation of dopaminergic neurons within the striatum of the weaver mouse (wv/wv), a neurological mutant characterized
via genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the one on hand laboratory version with a protracted affliction that mimics Parkinson's ailment. Structural and practical features of
intrastriatal mesencephalic neuron grafting into the weaver version are reviewed, together with histochemical correlates of graft survival and integration, numerical features of donor mobile survival, ultrastructural findings on
synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor comparable molecules, degrees of striatal amino acid receptors, and behavioural results of
unilateral and bilateral neuronal transplantations.
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